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2005
Lipids
U 0750
15- 202
Synthesis, Characterization and Transfection Activity of New Saturated and
Unsaturated Cationic Lipids. — Cationic lipids having a hydrophobic and a cationic
portion, linked by an etheral bond similar to the commercially available reagent
DOTMA, are prepared in order to evaluate the importance of chain length and number
of insaturations present in the hydrophobic part for transfection capacity. High in vitro
transfection efficiency of the cationic lipid/DNA complexes are observed with dodecyl
and farnesyl derivatives (Ia), (Ib), and especially (IIa). — (ARPICCO, S.;
CANEVARI, S.; CERUTI, M.; GALMOZZI, E.; ROCCO, F.; CATTEL*, L.;
Farmaco 59 (2004) 11, 869-878; Dip. Sci. Tecnol. Farm, Univ. Torino, I-10125 Torino,
Italy; Eng.) — H. Hoennerscheid
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