close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Medicinal chemistry
V 1100
Multidrug Resistance Reversal Activity of Permethyl Ningalin B Amide Deriva— Twenty amide derivatives including two dimers are prepared by coupling the
15- 235 tives.
parent carboxylic acid with amines. Substitution of the aryl ring with methoxy substituents, analogous to the peripheral aryl rings found in the ningalin B core enhance the
activity, cf. (Ia)—(Ic). This substitution pattern leads to a slight hypersensitization of
the HCT 116/VM 46 cell line to treatment with vinblastine or doxorubicin. Most interesting and significant derivatives (Id) and (Ie) display the MDR reversal potency of
some of the most potent leads, but lack the intrinsic, modest cytotoxic activity affording
a more than 100-fold therapeutic window. — (TAO, H.; HWANG, I.; BOGER*, D. L.;
Bioorg. Med. Chem. Lett. 14 (2004) 24, 5979-5981; Dep. Chem., Scripps Res. Inst.,
San Diego, La Jolla, CA 92037, USA; Eng.) — H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
14 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа