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2005
Medicinal chemistry
V 1100
Synthesis and Anticonvulsant Activity of New 2-Substituted-5-[2-(2-fluorophenand 1,2,4-Triazoles. — Six new heterocycles such as
15- 237 oxy)phenyl]-1,3,4-oxadiazoles
(I) are synthesized and their anticonvulsant effects are determined employing pentylenetetrazole (PTZ)-induced lethal convulsion and maximal electroshock (MES) tests.
Oxadiazole derivative (Ic) has considerable anticonvulsant activity both in PTZ and in
MES models, whereas compounds (Ia), (Ib), and (Id) display only mild effects in PTZ
and MES tests. It seems that the anticonvulsant activity of (Ic) is mediated by benzodiazepine receptors and other mechanisms. — (ALMASIRAD, A.; TABATABAI, S.
A.; FAIZI, M.; KEBRIAEEZADEH, A.; MEHRABI, N.; DALVANDI, A.; SHAFIEE*,
A.; Bioorg. Med. Chem. Lett. 14 (2004) 24, 6057-6059; Dep. Med. Chem., Fac.
Pharm., Tehran Univ. Med. Sci., Tehran, Iran; Eng.) —
H. Hoennerscheid
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