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2005
Ethers
P 0150
16- 061
Kilogram-Scale Synthesis of Bis(6-hydroxy-5,5-dimethylhexyl)ether (ESP24232),
a Novel Lipid Lowering Agent. — The development of a kilogram-scale synthesis of
the potential cardiovascular agent ESP24232 (VIII) by optimization of the existing procedure for large-scale production is described. For this purpose, toxic and hazardous
conditions as well as parameters difficult to reproduce are eliminated as much as possible. The developed manufacturing procedure proves to be reproducible in three parallel batches in terms of yield and quality of the final product. — (YANG, J.;
MUELLER, R.; POP, E.; DASSEUX, J.-L. H.; ONICIU*, D. C.; Org. Prep. Proced.
Int. 35 (2004) 6, 587-596; Esperion Ther., Pfizer Global Res. Dev., Ann Arbor,
MI 48108, USA; Eng.) — A. Forchert
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