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2005
Oxazole derivatives
R 0220
Studies on Stereoselective Synthesis of Ethyl anti-4-Substituted Pheand Their Antibacterial Activity. —
16- 114 nyl-2-oxo-1,3-oxazolidine-5-carboxylates
Title compounds (IV) are prepared stereoselectively from the N-Boc-β-amino alcohols
(III) by O-tosylation followed by SN2 cyclization (one-pot reaction). All products are
tested for their in vitro antibacterial activity against S.aureus, E.faecalis, and E.faecium.
All compounds show lower activity than linezolid and ciprofloxacin. —
(MADHUSUDHAN, G.; REDDY*, G. O.; RAMANATHAM, J.; DUBEY, P. K.;
Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 43 (2004) 12, 2683-2688;
Technol. Dev. Cent., Dr. Reddy's Lab. Ltd., Hyderabad 500 050, India; Eng.) —
H. Haber
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