close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Pyrazine derivatives
R 0550
Development of an Efficient and Selective Radioligand for Bradykinin B1 Receptor Occupancy Studies. — Based on its overall profile, compound (VII) is evaluated
16- 144 as
a potential radioligand. This compound is prepared by a route which is an adaptation
of an original synthesis to accommodate the preparation of [35S]-(VIII). The ex vivo
human BK B1 receptor occupancy study provides a rapid and reliable method for
determining the extent of a systemically-dosed test compound to occupy the human BK
B1 receptor overexpressed in the CNS of transgenic rats. — (SU*, D.-S.; et al.;
Bioorg. Med. Chem. Lett. 14 (2004) 24, 6045-6048; Dep. Med. Chem., Merck Res.
Lab., West Point, PA 19486, USA; Eng.) — H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
22 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа