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200517.fm Page 160 Friday, March 18, 2005 2:52 PM
2005
Pyridine derivatives
R 0380
A Novel Redox Reaction Between 8-Aza-5,7-dimethyl-2-trifluoromethyland Alkyl Mercaptoacetates. Facile Synthesis of CF3-Containing
17- 145 chromone
2-Pyridone Derivatives. — Treatment of the title chromones with mercaptoacetate (II)
results in formation of tricyclic compounds of type (III). They undergo reductive ring
opening to afford 2-pyridones like (V). The latter can easily be converted into the
unsaturated ketone (XII). Pyridone (V) shows a reactivity similar to (XII) indicating
that it behaves as masked α,β-unsaturated ketone. The reaction with various nucleophiles allows facile formation of different CF3-containing 2-pyridones which are of
biological interest. — (SOSNOVSKIKH*, V. Y.; BARABANOV, M. A.; USACHEV,
B. I.; J. Org. Chem. 69 (2004) 24, 8297-8304; Dep. Chem., Ural State Univ.,
Ekaterinburg 620083, Russia; Eng.) — Jannicke
200517.fm Page 161 Friday, March 18, 2005 2:52 PM
2005
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