close

Вход

Забыли?

вход по аккаунту

?

код для вставки
200517.fm Page 179 Friday, March 18, 2005 2:52 PM
2005
Fused pyrimidine derivatives
R 0515
Intramolecular Nucleophilic Aromatic Substitution Reaction of 2-Carboxamiand Its Application to the Synthesis of Secondary Aryl
17- 160 do-3-arylquinazolin-4-ones
Amines. — Treatment of amides (I) with NaH leads to rearranged products (II). For
the success of this method the presence of electron-withdrawing groups at the ortho or
para position of the N3-aryl group is essential. Secondary aryl amines, including diaryl
amines, can be synthesized by a modification of the novel method, involving the reaction of ester (III) with aromatic or aliphatic primary amines in the presence of NaOMe
base. It is assumed that the secondary amines are formed via amide formation, intramolecular SNAr reaction, and cleavage of the resultant tertiary amide. — (FUWA, H.;
KOBAYASHI, T.; TOKITOH, T.; TORII, Y.; NATSUGARI*, H.; Synlett 2004, 14,
2497-2500; Grad. Sch. Pharm. Sci., Univ. Tokyo, Bunkyo, Tokyo 113, Japan; Eng.)
— Klein
Документ
Категория
Без категории
Просмотров
0
Размер файла
29 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа