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2005
Benzopyran derivatives
R 0350
New 2-Bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and BioProperties. — Demethylation—lactonization of the biphenylcarboxylic acid
18- 123 logical
esters (I) and (III) in the presence of BBr3 provides access towards a novel heterocyclic
scaffold, namely title benzo[c]chromen-6-ones (II) and (IV). Although the prepared
benzochromenones possess only moderate enzyme inhibiting activity in the studied
assays, optimization of the substitution pattern should afford highly bioactive products.
— (GARINO, C.; BIHEL, F.; PIETRANCOSTA, N.; LARAS, Y.; QUELEVER, G.;
WOO, I.; KLEIN, P.; BAIN, J.; BOUCHER, J.-L.; KRAUS*, J.-L.; Bioorg. Med.
Chem. Lett. 15 (2005) 1, 135-138; Lab. Chim. Biomol., Fac. Sci. Luminy, Univ.
Mediterr., F-13288 Marseille, Fr.; Eng.) — Mischke
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