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2005
Pyridine derivatives
R 0380
Synthesis, Cardiovascular Activity, and Electrochemical Oxidation of Nitriles
5-Ethoxycarbonyl-2-methyl-thio-1,4-dihydropyridine-3-carboxylic Acid. —
18- 133 of
Nitriles (V) (13 examples) are obtained by six different methods. The most efficient
and simple procedure is a one-pot multicomponent condensation of ethyl acetoacetate
(I) with 2-cyanothioacetamide (II), aromatic aldehydes (III), and methyl iodide in the
presence of piperidine. The cardiovascular activity of several analogues of compounds
(V) and their toxicity are reported. — (KRAUZE, A.; BAUMANE, L.; SILE, L.;
CHERNOVA, L.; VILUMS, M.; VITOLINA, R.; DUBURS, G.; STRADINS, J.;
Chem. Heterocycl. Compd. (N. Y.) 40 (2004) 7, 876-887; Latv. Inst. Org. Synth.,
Riga 1006, Latvia; Eng.) — R. Staver
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