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2005
Pyridazine derivatives
R 0500
Some Pyrrole Substituted Aryl Pyridazinone and Phthalazinone Derivatives and
Antihypertensive Activities. — A variety of title compounds such as (III) and
18- 144 Their
(IV) (23 examples in all) are prepared by reaction of diones (I) with corresponding
amines (II) via Paal—Knorr pyrrole synthesis. Several of these pyridazinine compounds, e.g. derivatives (IIIb) and (IIIc), show antihypertensive activity. —
(DEMIRAYAK*, S.; KARABURUN, A. C.; BEIS, R.; Eur. J. Med. Chem. 39 (2004)
12, 1089-1095; Dep. Pharm. Chem., Fac. Pharm., Univ. Anadolu, TR-26470 Eskisehir,
Turk.; Eng.) — R. Staver
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