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2005
Quinoline derivatives
R 0410
A New Synthetic Approach of N-(4-Amino-2-methylquinolin-6-yl)(JTC-801) and Its Analogues and Their
19- 160 -2-(4-ethylphenoxymethyl)benzamide
Pharmacological Evaluation as Nociceptin Receptor (NOP) Antagonists. —
A novel synthetic procedure for the preparation of nociceptin receptor antagonist
JTC-801 (VIa) and some of its analogues is developed. The NOP receptor binding
affinity of derivative (VIc) is comparable with that of JTC-801 (VIa), while the other
compounds show decreased or no detectable NOP receptor binding activity. —
(SESTILI*, I.; BORIONI, A.; MUSTAZZA, C.; RODOMONTE, A.; TURCHETTO,
L.; SBRACCIA, M.; RIITANO, D.; DEL GIUDICE, M. R.; Eur. J. Med. Chem. 39
(2004) 12, 1047-1057; Dip. Farm., Ist. Super. Sanita, I-00161 Roma, Italy; Eng.) —
R. Staver
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