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2005
Carboxylic amides
Q 0490
Design, Synthesis and Pharmacological Evaluation of Some Novel 2-(4-NitropheAcrylamides as Potential Antiinflam20- 080 nyl)-3-methylthio-3-(substituted)arylamino
matory Agents. — 9 title compounds of type (IV) are prepared and tested for their antiinflammatory activities. Compounds (IVc) and (IVd) exhibit potent antiinflammatory
activities. Both compounds are also screened for their ulcerogenic potential in Albino
rats. A very low ulcer index is observed with both compounds, although higher than
that of the standard drug rofecoxib. — (CHHABRIA*, M. T.; PATEL, C. K.; JANI, M.
H.; Pharmazie 60 (2005) 2, 107-109; Dep. Pharm. Chem., Lallubhai Motilal Coll.
Pharm., Ahmedabad 380 009, India; Eng.) — M. Bohle
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