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2005
Fused pyrimidine derivatives
R 0515
Synthesis and Biological Activity of 3,4-Dihydroquinazolines for Selective T-Type
2+
Channel Blockers. — New regioisomeric series of 3,4-dihydroquinazoline
20- 151 Ca
derivatives containing both a biphenyl and an ω-aminoalkyl group (VII)/(VIII) are synthesized and evaluated for their inhibitory activities against two subtypes of T-type Ca2+
channels and N-type Ca2+ channels. Among them, derivative (VIIIa) is identified as potent and selective T-type Ca2+ channel blocker. — (RHIM, H.; LEE, Y. S.; PARK, S. J.;
CHUNG, B. Y.; LEE*, J. Y.; Bioorg. Med. Chem. Lett. 15 (2005) 2, 283-286; Dep.
Chem., Kyung Hee Univ., Seoul 130-701, S. Korea; Eng.) — R. Staver
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