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2005
Multi-membered N-heterocycles
R 0690
Synthesis of 5-Phenyl-5,6,7,8-tetrahydro-1,6-naphthyridines and 5-Phenylas Potential D1 Receptor Ligands.
20- 165 -6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines
— A new access to the title naphthyridines and their ring-extended azepine analogues
[cf. (VIII), (X), (XV)] is developed by first preparing the functional pyridine moiety
followed by intramolecular cyclization forming the partially hydrogenated ring. None
of the fused pyridines prepared shows appreciable affinity to any of the dopamine receptors tested. — (HUSSENETHER, T.; TROSCHUETZ*, R.; J. Heterocycl. Chem.
41 (2004) 6, 857-865; Dep. Med. Chem., Emil Fischer Cent., Friedrich-Alexander
Univ., D-91052 Erlangen, Germany; Eng.) — A. Forchert
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