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2005
Nucleic acids
U 0700
Synthesis and Biological Evaluation of Novel 1'-Branched and Spironucleosides
— The anionic reactivity of the cyano function and especially the addition
20- 203 Analogues.
of organolithium reagents both to protected bromo uridine and 2'-deoxy uridine derivatives is investigated as well as the antiviral and antitumoral activity of some of the new
anomeric spironucleosides and of 2',3'-didehydro-2',3'-dideoxy nucleoside (IX), a
structural analogue of known anti-HIV agents. None of the compounds reveals antiviral
activity, however, spironucleoside (IV) and didehydronucleoside (IX) display cytostatic activity against murine leukemia and human T-lymphocyte cells. —
(CHATGILIALOGLU, C.; FERRERI, C.; GIMISIS*, T.; ROBERTI, M.;
BALZARINI, J.; DE CLERCQ, E.; Nucleosides, Nucleotides Nucleic Acids 23
(2004) 10, 1565-1581; Lab. Org. Chem., Univ. Athens, GR-15771 Athens, Greece;
Eng.) — H. Hoennerscheid
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