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2005
Thiazole derivatives
R 0260
Amides and Hydrazides of Acylpyruvic Acids. Part 11. Synthesis and Biological
of N-(1,3-Thiazol-2-yl)-4-aryl-2-hydroxy-4-oxo-2-butenoic Amides. —
21- 137 Activity
Compounds of type (I) (25 examples) are synthesized by known methods and studied
for their pharmacological activities. Some of these derivatives exhibit antimicrobial,
antiinflammatory, and analgetic activities. For all derivatives, only weak toxicity is
observed (LD50 >1000 mg/kg). — (KOZ'MINYKH, V. O.; MILYUTIN, A. V.;
MAKHMUDOV, R. R.; BELYAEV, A. O.; KOZ'MINYKH, E. N.; Khim.-Farm. Zh.
38 (2004) 12, 21-24; Permskii gos. pedagog. univ., Perm', Russia; Russ.) — Klein
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