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2005
Nucleic acids
U 0700
Nucleosides. Part 11. Synthesis and Antiviral Evaluation of 5'-AlkylthioQuinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine
21- 210 -5'-deoxy
Analogues. — Only the ß-anomer of (III) is obtained in the direct glycosylation using
the Verbruggen's silylation method. (III) only undergoes coupling with dialkyl sulfides
after protection of the 4-amino group, cf. derivatives (IV) and (IX). The products (VI)
and (X) are screened for antiviral activities against HSV-1 and Epstein—Barr virus and
found to be inactive at non-cytotoxic concentrations. — (CHIEN, T.-C.; CHEN, C.-S.;
YU, F.-H.; CHERN*, J.-W.; Chem. Pharm. Bull. 52 (2004) 12, 1422-1426; Sch.
Pharm., Coll. Med., Natl. Taiwan Univ., Taipei 100, Taiwan; Eng.) — K. Woydowski
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