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2005
Pyrazole derivatives
R 0180
Synthesis and Biological Evaluation of New Phenidone Analogues as Potential
Cyclooxygenase (COX-1 and COX-2) and Human Lipoxygenase (5-LOX)
22- 115 Dual
Inhibitors. — 9 acylated title compounds of type (III) are prepared and tested as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX)
inhibitors. Only the non-acylated compound (I) shows considerable activity against
both COX-1 and COX-2 enzymes, comparable to the reference compound phenidone.
— (CUSAN, C.; SPALLUTO, G.; PRATO, M.; ADAMS, M.; BODENSIECK, A.;
BAUER, R.; TUBARO, A.; BERNARDI, P.; DA ROS*, T.; Farmaco 60 (2005) 1,
7-13; Dip. Sci. Farm., Univ. Trieste, I-34127 Trieste, Italy; Eng.) — M. Bohle
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