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2005
Pyridine derivatives
R 0380
Search for Histamine H3 Receptor Antagonists with Combined Inhibitory Potency
at Nτ-Methyltransferase: Ether Derivatives. — A series of title compounds of type
22- 144 (V),
(VII), (X) or (XII) is prepared and tested as histamine H3 receptor antagonists.
Some compounds such as (XII) have a relatively high HMT inhibitory potency and
others such as (V), (VII) or (X) are potent histamine H3 receptor ligands. — (APELT,
J.; GRASSMANN, S.; LIGNEAU, X.; PERTZ, H. H.; GANELLIN, C. R.; ARRANG,
J.-M.; SCHWARTZ, J.-C.; SCHUNACK, W.; STARK*, H.; Pharmazie 60 (2005) 2,
97-106; Inst. Pharm. Chem., Johann Wolfgang Goethe-Univ., D-60439 Frankfurt/M.,
Germany; Eng.) — M. Bohle
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