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2005
Pyrazine derivatives
R 0550
Non-Imidazole Histamine H3 Ligands. Part 3. New 4-n-Propylpiperazines as
Histamine H3-Antagonists. — A series of 10 title compounds of type
22- 163 Non-Imidazole
(III), (V), (VII), and (IX) is prepared. The compounds are tested for their histamine
H3-antagonistic effects in vitro. The thiazole derivatives display a higher activity than
their oxazole analogues. (IIIa) is chosen as a new lead for non-imidazole histamine
H3-receptor antagonists. — (WALCZYNSKI*, K.; ZUIDERVELD, O. P.;
TIMMERMAN, H.; Eur. J. Med. Chem. 40 (2005) 1, 15-23; Dep. Synth. Technol.
Drugs, Med. Acad., PL-90-145 Lodz, Pol.; Eng.) — M. Bohle
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