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2005
Thiazole derivatives
R 0260
Synthesis and Biological Activity of New 2-Amino-4-[3-methyl-3-(5,6,7,8-tetrahyDerivatives. — The oxidation of alcohol (I) with
23- 125 dro-2-naphthyl)cyclobutyl]thiazole
Na2Cr 2O7 followed by condensation of the ketone thus obtained with thiourea gives rise
to aminothiazole (IV). Compound (IV) is used as a convenient starting compound in
the synthesis of derivatives (VI), (VIII) and (X), which show moderate antibacterial activity. — (KOPARIR, M.; CANSIZ, A.; AHMEDZADE, M.; Russ. J. Org. Chem. 40
(2004) 12, 1813-1818; Dep. Chem., Fac. Arts Sci., Firat Univ., TR-23119 Elazig,
Turk.; Eng.) — R. Staver
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