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2005
Pyrazine derivatives
R 0550
Synthesis and Pharmacological Activity of ω-(4-Phenylpiperazin-1-yl)alkylthio— A series of title compounds is synthesized either by amination of bro23- 163 pyrimidines.
mides of type (I) and (VII) with piperazine (II) or by reaction of sodium salts (IV) and
(XI) with chloride (V). In some cases, the piperazine nitrogen is quaternized by BnBr.
Some of these compounds exhibit hypotensive activity which is comparable with the
activity of papaverine. — (REZNIK, V. S.; PASHKUROV, N. G.; MIKHAILOV, A. S.;
AKAMSIN, V. D.; GALYAMETDINOVA, I. V.; ZOBOV, V. V.; LANTSOVA, A. V.;
Khim.-Farm. Zh. 38 (2004) 12, 11-14; Inst. org. fiz. khim. im. Arbuzova Kazanskogo
nauchno tsentra Ross. Akad. nauk, Kazan' 420083, Russia; Russ.) — Klein
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