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2005
Receptor binding activity
X 0280
Design and Synthesis of Novel Platelet Fibrinogen Receptor Antagonists with
Scaffold. A Systematic Study. — A series of novel
23- 235 2H-1,4-Benzoxazine-3(4H)-one
platelet fibrinogen receptor antagonists of type (I) and (II) is prepared and the effect of
the structure variation is studied systematically. In contrast to the generally accepted
model, compounds containing ethyl esters as aspartate mimetics are in general more
active than the corresponding free acids. — (DOLENC*, M. S.; et al.; Eur. J. Med.
Chem. 40 (2005) 1, 25-49; Fac. Pharm., Univ. Ljubljana, 1000 Ljubljana, Slovenia;
Eng.) — M. Bohle
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