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2005
Indole derivatives
R 0140
The Design and Synthesis of Novel 3-[2-Indol-1-yl-ethyl]-1H-indole Derivatives
Selective Inhibitors of CDK4. — A series of title compounds (I) is synthesized as
24- 113 as
inhibitors of CDK4 which are selective compared to CDK2. They are conceived as
non-planar analogues of fascaplysin. — (AUBRY, C.; PATEL, A.; MAHALE, S.;
CHAUDHURI, B.; MARECHAL, J.-D.; SUTCLIFFE, M. J.; JENKINS*, P. R.;
Tetrahedron Lett. 46 (2005) 9, 1423-1425; Dep. Chem., Univ. Leicester, Leicester
LE1 7RH, UK; Eng.) — Mais
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