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2005
Anticarcinogenic activity
X 0070
Synthesis of Nonclassical Quinazolinone Antifolates as Thymidylate Synthase Inand Their Antitumor Activity in vitro. — The nonclassical quinazolinone
24- 214 hibitors
analogues (I) and (II), in which the glutamic acid moiety of the classical antifolates is
substituted by phenylglycine, phenylalanine or aminobenzoic acid derivatives, are synthesized and screened as lipophilic inhibitors of thymidylate synthase (TS). Most effective are the compounds (Ia) and (Ib). — (BAEK*, D.-J.; KANG, T.-B.; KIM, H. J.;
Bull. Korean Chem. Soc. 25 (2004) 12, 1898-1906; Dep. Chem., Sang Myung Univ.,
Seoul 110-743, S. Korea; Eng.) — H. Haber
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