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2005
Pyrrole derivatives
R 0120
Bis(aminopyrrolidine)-Derived Ureas (APUs) as Potent MCH1 Receptor Antago— A new class of MCH1 receptor ligands (VIII) containing an urea moiety,
25- 112 nists.
derived from two substituted aminopyrrolidine subunits, is synthesized. Thiophene
(VIIIa) shows the most potent binding affinity and is also a functional antagonist. Preliminary experiments with the APU core indicate that a stereochemistry as in (IX) is
preferred to give the most potent examples. — (DYCK*, B.; et al.; Bioorg. Med.
Chem. Lett. 15 (2005) 4, 999-1004; Dep. Med. Chem., Neurocrine Biosci., Inc.,
San Diego, CA 92121, USA; Eng.) — H. Hoennerscheid
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