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2005
Indole derivatives
R 0140
2-(o-Aminoaryl)indole Derivatives via the Coupling-Cyclization of o-Alkynylawith o-Halotrifluoroacetanilides in the Presence of a Palladium Catalyst.
25- 114 nilines
— o-Halotrifluoroacetanilides (I) and o-ethynylanilines (II) undergo a Pd-catalyzed
reaction to give the indole derivatives (III) directly. The intermediacy of diarylalkynes
of type (IV) is rationalized by independent synthesis of (IV) and its cyclization to (IIIa)
without the need od a Pd-catalyst. Furthermore it is demonstrated, that arylalkynes
without an o-amino substituent give the expected Sonogashira diarylalkynes (VI) under
the Pd-catalytic conditions. — (ARCADI, A.; CACCHI*, S.; FABRIZI, G.;
MARINELLI, F.; PARISI, L. M.; Heterocycles 64 (2004) 475-482; Dip. Stud. Chim.
Tecnol. Sostanze Biol. Attive, Univ. La Sapienza, I-00185 Roma, Italy; Eng.) —
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