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2005
Pyridine derivatives
R 0380
Synthesis and SAR Studies of 3-Phenoxypropyl Piperidine Analogues as ORL1
Receptor Agonists. — A series of title compounds of type (VI), (VIII), and (X)
25- 140 (NOP)
is prepared and their activity as ORL1 (NOP) receptor agonists is studied. Compound
(X) shows high affinity with good functional potency and efficacy and modest selectivity. — (PALIN*, R.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 3, 589-593; Dep.
Med Chem., Organon Lab. Ltd., Newhouse, Lanarkshire ML1 5SH, UK; Eng.) —
M. Bohle
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