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2005
Triazine derivatives
R 0655
1-Aryl-4,6-diamino-1,2-dihydrotriazine as Antimalarial Agent: A New Synthetic
— The one-pot synthesis of triazines (IV) under microwave irradiation mini25- 162 Route.
mizes yield and energy loss. This condensation reaction is best performed under anhydrous conditions. Compounds (IV) are tested for antimalarial activity against drug
sensitive and resistant parasite lines. Triazine derivative (IVc) shows good in vitro
antiplasmodial activity while (IVd) and (IVe) also display some activity in both P.
falciparum strains. — (KIDWAI*, M.; MOTHSRA, P.; MOHAN, R.; BISWAS, S.;
Bioorg. Med. Chem. Lett. 15 (2005) 4, 915-917; Dep. Chem., Univ. Delhi, Delhi
110 007, India; Eng.) — H. Hoennerscheid
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