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2005
Multi-membered N-heterocycles
R 0690
Acylation of 6,7,8,9-Tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylacetonitrile.
The acylation direction of the title compound (I) depends on the conditions and
25- 166 —
nature of the acylating agent. The acylation with Ac2O and (Et-CO)2O at 25 °C in Et3N
leads to N-acyl derivatives (III), while the reaction in corresponding boiling anhydrides
gives rise to the corresponding C-acyl products (IV). The acylation with carboxylic acid
anhydrides (V) and chlorides (VIII) leads exclusively to the C-acylated derivatives (VI)
and (VIII). — (MAKEI, A. P.; VOLOVENKO, Y. M.; NAZARENKO, K. G.;
TOLMACHEV, A. A.; Russ. J. Org. Chem. 40 (2004) 12, 1810-1812; Taras
Shevchenko Univ., Kiev 252033, Ukraine; Eng.) — R. Staver
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