close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Multi-membered N-heterocycles
R 0690
The Development of Potent and Selective Bisarylmaleimide GSK3 Inhibitors. —
the 1,7-indole positions of a 3-aryl-4-(3-indolyl)maleimide with a ring sys25- 168 Spanning
tem is used to design novel, potent and selective GSK3 inhibitors. Compounds (V) and
(XI) reveal single digit nanomolar GSK3 inhibitory activity and dramatically improved
selectivity vs. PKCβII, CDK2, and CDK4. In addition, these compounds inhibit tau
phosphorylation in cells and are effective in lowering plasma glucose in a model of type
2 diabetes, and hold promise as potential agents for diabetes and Alzheimer's disease.
— (ENGLER*, T. A.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 4, 899-903; Lilly
Res. Lab., Lilly Corp. Cent., Eli Lilly Co., Indianapolis, IN 46285, USA; Eng.) —
H. Hoennerscheid
2005
Документ
Категория
Без категории
Просмотров
0
Размер файла
29 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа