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2005
Fused pyridine derivatives
R 0450
1,8-Naphthyridines. Part 5. Novel N-Substituted 5-Amino-N,N-diethyl-9-isoproas Potent Antiin26- 086 pyl[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides,
flammatory and/or Analgesic Agents Completely Devoid of Acute Gastrolesivity.
— Ongoing research leads to the synthesis of novel set of the title compounds such as
(V) and (VIII). The biological results are discussed in detail. (Vc), (Vd) and (VIIIb)
show a statistically significant sedative effect. (Vc) and (Vd) showing significant antinociceptive activity do not reduce mice spontaneous mobility. — (GROSSI, G.; DI
BRACCIO, M.; ROMA*, G.; BALLABENI, V.; TOGNOLINI, M.; BAROCELLI, E.;
Eur. J. Med. Chem. 40 (2005) 2, 155-165; Dip. Sci. Farm., Univ. Studi Genova,
I-16132 Genova, Italy; Eng.) — K. Schneider
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