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2005
Triazine derivatives
R 0655
Synthesis and Antibacterial Activity of 2,4,6-Tri-substituted s-Triazines. —
of cyanuric chloride (I) with benzylamines (II) in the presence of 18-crown-6
26- 100 Treatment
leads to formation of triazines (III). Trimerization reaction of phenyl acetonitriles and
benzyl alcohols with cyanuric chloride yields the triazines (IV) and (V), respectively.
The triazines are tested against three representative Gram-positive and three Gram-negative organisms. The test compounds exhibit moderate activity. Benzyl substituted triazine (IVa) shows remarkable in vitro antibacterial activities comparable to penicillin
and streptomycin. — (SRINIVAS, K.; SRINIVAS, U.; RAO*, V. J.;
BHANUPRAKASH, K.; KISHORE, K. H.; MURTY, U. S. N.; Bioorg. Med. Chem.
Lett. 15 (2005) 4, 1121-1123; Org. Div.-II, Indian Inst. Chem. Technol.,
Hyderabad 500 007, India; Eng.) — H. Hoennerscheid
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