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2005
Vitamins
U 0900
26- 145
Synthesis of the Enantiomer of 1α,25-Dihydroxy Vitamin D3 (Calcitriol) and
a Diastereomer of 1α,25-Dihydroxy Vitamin D3 Differing from Natural Product
in Configuration at All but One Asymmetric Carbon Atoms. — ent-Calcitriol
(VIb) and its diastereomer (VIa) with S-configuration at the C-1 atom are synthesized
via the coupling of sulfone (I) with appropriate aldehyde (II) followed by acetylation
and reduction to the derivatives (IV) and (V). The necessary synthons (II) are obtained
from vitamin D3 by multi-step procedures. (Yields in part not given or in g). —
(ACHMATOWICZ, B.; PRZEZDZIECKA, A.; WICHA*, J.; Pol. J. Chem. 79 (2005)
2, 413-428; Inst. Org. Chem., Pol. Acad. Sci., PL-01-224 Warsaw, Pol.; Eng.) —
R. Staver
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