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2005
Sulfinic acids
Q 0570
Subtilisin-Catalyzed Resolution of N-Acyl Arylsulfinamides. — Subtilisin E is
as the most suitable hydrolase examined in the present work for the prepara27- 094 identified
tion of enantiopure arylsufinamides. Its reactivity and enantioselectivity toward N-acyl
arylsulfinamides depend on the N-acyl group. Simple N-acyl groups, such as N-acetyl
and N-butanoyl, do not react. Sulfinamides (II) are resolved in gram quantities. Modeling of tetrahedral intermediates bound to the hydrolase are made to throw light on the
high enantioselectivity of these reactions. — (SAVILE, C. K.; MAGLOIRE, V. P.;
KAZLAUSKAS*, R. J.; J. Am. Chem. Soc. 127 (2005) 7, 2104-2113; Dep. Chem.,
McGill Univ., Montreal, Que. H3A 2K6, Can.; Eng.) — Klein
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