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2005
Oxadiazole derivatives
R 0290
Synthesis of Some New 2-(2-Fluoro-4-biphenylyl)propionic Acid Derivatives as
Antiinflammatory Agents. — A variety of analogues of flurbiprofen con27- 131 Potential
taining different heterocyclic moieties is prepared and evaluated for their anti-inflammatory activity. The compounds tested demonstrate anti-inflammatory activities from
66 to 94% inhibition at 10 mg/kg oral dose in carrageenan induced paw edema model.
The most active derivatives (X), (XIII) and (XVa) show also a significant reduction in
ulcerogenic activity compared to flurbiprofen as well as a reduced lipid peroxidation.
— (AMIR*, M.; KUMAR, S.; Pharmazie 60 (2005) 3, 175-180; Dep. Pharm. Chem.,
Hamdard Univ., New Delhi 110 062, India; Eng.) — R. Staver
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