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2005
Alkaloids
U 0600
27- 194
Synthesis and Monoamine Transporter Affinity of New 2β-Carbomethoxy-3β-[4-(substituted thiophenyl)]phenyltropanes: Discovery of a Selective SERT
Antagonist with Picomolar Potency. — Ten new thiophenephenyltropanes are synthesized and evaluated for their monoamine transporter potencies and selectivity. All
compounds exhibit greater affinity for SERT than dopamine transporter and norepinephrine transporter. The most potent compounds at SERT are the unsubstituted
thiophenes (VI), (VIII), (XII), and (XIII) (no yields given). — (TAMAGNAN*, G.;
ALAGILLE, D.; FU, X.; KULA, N. S.; BALDESSARINI, R. J.; INNIS, R. B.;
BALDWIN, R. M.; Bioorg. Med. Chem. Lett. 15 (2005) 4, 1131-1133; Dep.
Psychiatr., Yale Univ., West Haven, CT 06516, USA; Eng.) — H. Hoennerscheid
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