close

Вход

Забыли?

вход по аккаунту

?

код для вставки
2005
Antifungal activity
X 0090
Synthesis and Antibacterial Activity of 1-[1,2,4-Triazol-3-yl] and 1-[1,3,4-Thia— Triazole
27- 210 diazol-2-yl]-3-methylthio-6,7-dihydrobenzo[c]thiophen-4(5H)ones.
and thiadiazole derivatives (I), (II), and (III) are derived from the parent compound ethyl dihydrobenzothiophenone carboxylate by simple procedures. Some of the compounds synthesized exhibit moderate to good activity against Gram-positive strains.
Compound (Ib) is the most active derivative against S. aureus, while (Ia) and (IIa) are
the most potent compounds against S. epidermis. Thiadiazole derivatives (III) show
significant activity against B. subtilis. However, none of the compounds exerts a significant effect against Gram-negative strains or fungi. — (TEHRANCHIAN, S.;
AKBARZADEH, T.; FAZELI, M. R.; JAMALIFAR, H.; SHAFIEE*, A.; Bioorg.
Med. Chem. Lett. 15 (2005) 4, 1023-1025; Dep. Med. Chem., Fac. Pharm., Tehran
Univ. Med. Sci., Tehran, Iran; Eng.) — H. Hoennerscheid
Документ
Категория
Без категории
Просмотров
0
Размер файла
14 Кб
Теги
1/--страниц
Пожаловаться на содержимое документа