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2005
Ring closure reactions
Ring closure reactions
O 0130
Biaryls and Heterobiaryls as α-Glucosidase and Protein Tyrosine Phosphatase In— A ring transformation reaction is used for the preparation of some highly
28- 037 hibitors.
functionalized biaryls (III), phenanthrenes (V), and the pyrene derivative (VIII). All
compounds are screened for their α-glucosidase and protein tyrosine phosphatase inhibitory properties. (IIIa), (V) and (VIII) display better α-glucosidase activity than the
standard drug acarbase. — (SHARON, A.; PRATAP, R.; TRIPATHI, B.;
SRIVASTAVA, A. K.; MAULIK, P. R.; RAM*, V. J.; Bioorg. Med. Chem. Lett. 15
(2005) 5, 1341-1344; Div. Med. Chem., Cent. Drug Res. Inst., Lucknow 226 001,
India; Eng.) — H. Haber
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