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2005
Fused pyrrole derivatives
Fused pyrrole derivatives
R 0160
cis-6-Oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-Oxo-HexahydropyrroBased Scaffolds: Design, Rationale, Synthesis and Cysteinyl Pro28- 127 lo[3,2-c]pyrazole
teinase Inhibition. — Synthetic routes to the title compounds based scaffolds (IV) and
(IX) are described. Both substances are screened against cathepsins K, L, S, and B, as
well as the parasitic proteinases cruzain and CPB. — (WANG, Y.; BENN, A.; FLINN,
N.; MONK, T.; RAMJEE, M.; WATTS*, J.; QUIBELL*, M.; Bioorg. Med. Chem.
Lett. 15 (2005) 5, 1327-1331; Amura Ther. Ltd., Comberton, Cambridge CB3 7AJ,
UK; Eng.) — H. Haber
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