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2005
Pyridine derivatives
Pyridine derivatives
R 0380
The Synthesis of Substituted Bipiperidine Amide Compounds as CCR3 Antago— The SAR of a series of bipiperidine amides, e.g. (VI) and (XIV), is studied
28- 153 nists.
and different synthetic routes for the modification of the amide, the aryl, and the
piperidine moiety are described. Some potent compounds such as (XIV) are separated
into their enantiomers by HPLC on a chiral column (some yields not given). —
(TING*, P. C.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 5, 1375-1378;
Schering-Plough Res. Inst., Kenilworth, NJ 07033, USA; Eng.) — H. Haber
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