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2005
Quinoline derivatives
Quinoline derivatives
R 0410
A Convenient Synthesis of Quinolin-2(1H)-one Ring System as Precursor of AcDrugs. — α-Ketocarboxylic acids can be readily alkylated with o-nitrobenzyl
28- 155 tive
chlorides to give α-hydroxy esters in moderate to good yields. Reductive cyclization
with iron results in formation of 3-hydroxy-3,4-dihydroquinolines as precursors of potential pharmaceuticals. — (GIUGLIO-TONOLO, G.; TERME, T.; VANELLE*, P.;
Synlett 2005, 2, 251-254; Lab. Chim. Org. Pharm., Fac. Pharm., CNRS,
F-13385 Marseille, Fr.; Eng.) — Mais
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