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2005
Thiadiazine derivatives
Thiadiazine derivatives
R 0660
Synthesis and Antimicrobial Activity of 1,3,5-Thiadiazines and Their Isomerism
1,3,5-Triazines. — A series of 2,6-diimino-4-aminothiadiazines (V) (7 examples)
28- 175 into
are synthesized, which suffer isomerization into triazines (VI) on treatment with NaOH
in a H2O/EtOH solution. Screening of thiadiazines (V) for antimicrobial activity shows
that compounds (Vc) and (Ve) are highly active against S. typhi and B. subtilis, whereas
compounds (Vb) and (Vf) are highly active against A. niger. — (DEOHATE*, P. P.;
BERAD, B. N.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 44 (2005) 3,
638-642; Postgrad. Dep. Chem., Shri Shivaji Sci. Coll., Amravati 444 603, India;
Eng.) — A. Forchert
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