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2005
Organo-selenium compounds
Organo-selenium compounds
S 0130
Novel and Orally Bioavailable Inducible Nitric Oxide Synthase Inhibitors. Synand Evaluation of Optically Active 4,5-Dialkyl-2-iminoselenazolidine De28- 185 thesis
rivatives. — A series of novel optically active 4,5-dialkyl-2-iminoselenazolidine derivatives (VII) and (VIII) is synthesized by two synthetic methods. The pathway via the
chromatographic separation of the isomers (V) and (VI) is also used for the synthesis
of the enantiomers of (VII) and (VIII). All compounds are examined for their in vitro
and in vivo inhibitory activity against iNOS. (VII) shows the best selectivity for iNOS
and strong inhibitory activity. — (UEDA*, S.; TERAUCHI, H.; SUZUKI, K.; YANO,
A.; MATSUMOTO, M.; KUBO, T.; MINATO, H.; ARAI, Y.; TSUJI, J.-I.;
WATANABE, N.; Bioorg. Med. Chem. Lett. 15 (2005) 5, 1361-1366; Chem. Res.
Lab., Dainippon Pharm. Co., Ltd., Suita, Osaka 564, Japan; Eng.) — H. Haber
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