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2005
Isoindole derivatives
R 0140
Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cy— A mild, efficient and widely applicable approach to isoindolin-1-ones and
29- 121 clization.
related compounds is reported. The regioselective outcome of the cyclization is dependent on the substituents of the starting benzamide and the nature of the electrophile.
This method can also be applied successfully to the synthesis of the alkaloid cepharanone B (VII). — (YAO, T.; LAROCK*, R. C.; J. Org. Chem. 70 (2005) 4, 1432-1437;
Dep. Chem., Iowa State Univ., Ames, IA 50011, USA; Eng.) — Jannicke
2005
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