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2005
Benzimidazole derivatives
R 0200
Synthesis of 2,3,5,6-Tetrahydro-3H-imidazo[2,1-b][1,3,5]benzotriazepines and
Oxidative Ring Contraction into 1-(4,5-Dihydro-1H-imidazol-2-yl)29- 130 Their
-1H-benzimidazoles. — The structures of compound (IIIb) and (IVa) are determined
by X-ray analysis. Some few pharmacological results of the compounds are discussed.
(IV) have low affinity for both rat central I2 and α2 receptors whereas (VIa) and (VIb)
display selectivity for the imidazoline I2 receptors as compared to the α2-adrenergic
receptors. — (SACZEWSKI*, F.; KOBIERSKA, E.; TYACKE, R. J.; HUDSON, A.
L.; NUTT, D. J.; GDANIEC, M.; Farmaco 60 (2005) 2, 127-134; Dep. Chem.
Technol. Drugs, Med. Univ. Gdansk, PL-80-416 Gdansk, Pol.; Eng.) — K. Schneider
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