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2005
Quinoline derivatives
R 0410
Synthesis of Substituted Quinolines by Electrophilic Cyclization of N-(2-Alky— A new approach to 3-substituted quinolines, which are difficult to pre29- 155 nyl)anilines.
pare using previous methods, is developed. The reaction takes place under very mild
reaction conditions and tolerates considerable functionality. The resulting iodoquinolines can be further used in the Suzuki reaction [cf. (IIc)] and Buchwald—Hartwig
amination [cf. (IId)]. — (ZHANG, X.; CAMPO, M. A.; YAO, T.; LAROCK*, R. C.;
Org. Lett. 7 (2005) 5, 763-766; Dep. Chem., Iowa State Univ., Ames, IA 50011, USA;
Eng.) — Steudel
2005
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