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2005
Fused pyrimidine derivatives
R 0515
3H-Quinazolin-4-ones as a New Calcilytic Template for the Potential Treatment
Osteoporosis. — Starting from a high throughput hit various kinds of compounds
29- 164 of
such as (III), (V) and (VII) are synthesized. The latter shows 50-fold potency increase
compared to the parent compound. Injection of (VII) induced a rapid but transient
dose-related increase in plasma parathyroid hormone levels. —
(SHCHERBAKOVA*, I.; BALANDRIN, M. F.; FOX, J.; GHATAK, A.; HEATON, W.
L.; CONKLIN, R. L.; Bioorg. Med. Chem. Lett. 15 (2005) 6, 1557-1560; NPS
Pharm., Inc., Univ. Utah Res. Park, Salt Lake City, UT 84108, USA; Eng.) —
K. Schneider
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