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2005
Multi-membered N-heterocycles
R 0690
Synthesis and SAR of Diazepine and Thiazepine TACE and MMP Inhibitors. —
this newly synthesized series of compounds such as (VII) and (IX), the deriv29- 178 Among
ative (VII) is the most interesting one which shows excellent in vivo activity in the
mouse LPS-induced TNF-α release assay as well as oral efficacy in the CIA model of
arthritis (no yields given). — (ZASK*, A.; et al.; Bioorg. Med. Chem. Lett. 15 (2005)
6, 1641-1645; Wyeth Res., Pearl River, NY 10965, USA; Eng.) — K. Schneider
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